Adds artificial doublets to an existing dataset
Usage
addDoublets(
x,
clusters,
dbr = (0.01 * ncol(x)/1000),
only.heterotypic = TRUE,
adjustSize = FALSE,
prefix = "doublet.",
...
)Arguments
- x
A count matrix of singlets, or a
SummarizedExperiment-class- clusters
A vector of cluster labels for each column of `x`
- dbr
The doublet rate
- only.heterotypic
Whether to add only heterotypic doublets.
- adjustSize
Whether to adjust the library sizes of the doublets.
- prefix
Prefix for the colnames generated.
- ...
Any further arguments to
createDoublets.
Value
A `SingleCellExperiment` with the colData columns `cluster` and `type` (indicating whether the cell is a singlet or doublet).
Examples
sce <- mockDoubletSCE(dbl.rate=0)
sce <- addDoublets(sce, clusters=sce$cluster)